Curriculum Vitae
Jerold A. Last
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Department of Internal Medicine Division of Pulmonary/Critical Care Medicine 6519 GBSF University of California Davis, California 95616 Phone:(530) 752-6230 Fax: (530) 752-8632 Email: jalast@ucdavis.edu |
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Research Interests
General
Animal models of acute and chronic lung fibrosis; animal models of asthma; collagen biochemistry; lung toxicology; environmental toxicology.
Specific
Collagen metabolism by fibrotic lungs; inhalation toxicology; interactions of mixtures of air pollutants or other toxicants; ELISA as a technology for environmental monitoring in developing countries.
Education
| Date | Institution | Degree |
|---|---|---|
| 1955-1959 | University of Wisconsin, Madison, Wisconsin |
B.S., Chemistry |
| 1959-1961 | University of Wisconsin, Madison, Wisconsin |
M.S., Biochemistry |
| 1962-1965 | Ohio State University, Columbus, Ohio |
Ph. D, Biochemistry |
| 1966-1967 | New York University, New York City, New York |
Postdoctoral Studies |
Research/Professional Experience
| 1971-1973 | Managing Editor, Proceedings of the National Academy of Sciences, USA |
| 1973-1976 | Research Associate, Chemistry Department, Harvard University |
| 1985-1994 | Unit Leader, Respiratory Disease Unit, California Regional Primate Research Center |
| 1985-2004 | Director, University of California Toxic Substances Research and Teaching Program |
| 1985-1998 | Vice-chair, Department of Internal Medicine, UC Davis Medical School |
| 1976-Present | Assistant Professor, Associate Professor, and Professor, Department of Internal Medicine (Pulmonary), School of Medicine, University of California, Davis. |
Editorial Boards
Toxicology (1980-1984); Experimental Lung Research (1983-1987); Toxicology and Applied Pharmacology (1984-2008).
Honors and Awards
Fulbright Lecturer, University of the Republic, Montevideo, Uruguay, 1983 and 1999; Frank R. Blood Award, Society of Toxicology, 1980; ICI Travelling Lectureship Award, Society of Toxicology, 1992; FASEB Visiting Scientist (Minority Access to Research Careers [MARC] Program), 1982, 1985, 1991; Faculty Research Award, School of Medicine, UC Davis, 1990; Joan Oettinger Memorial Research Award, University of California, Davis, 1979 and 1983; Distinguished Public Service Award, University of California, Davis, 2003; Visiting Team Member, NHLBI Co-operative Program on Lung Disease, German Federal Republic, 1986 and 1987; American Cancer Society Postdoctoral Fellow, 1967-1968.
Study Sections and Peer Review Panels: Member, NHLBI Special Study Section, Pulmonary Adult SCORs, l986; Pulmonary Pediatric SCORs, 1991; Ad Hoc Review Committee, RFP, "Production of Toxic Oxygen Species in Acute Lung Injury", l984; Special Member, RAP Study Section, l988, 1989; VA Merit Review Board, Respiratory, l980-l983; Chair, Project Review Panel, Pulmonary and Immunotoxicology Research Programs, U.S. Department of Energy, 1989; DOE Review panel Berylium Programs, 1996; Site Visit Team, Los Alamos Nat. Lab, 1994; Visiting Team Member, NIOSH Intramural Program Review, Morgantown, W. Va., 1990. Amer. Lung Assn. of CA Research Grants, 1980-1986, Chair, 1984-86. EPA Study Sections, Health Effects of Air Pollutants, 1995, 1997; Effects of Complex Mixtures, 1997.
Selected Publications (from a total of more than 150):
Stanley, W. M., Jr., M. A. Smith, M. B. Hille and J. A. Last. Translation
of the genetic message. I. Preparation of oligonucleotide messengers
of known base sequence. Cold Spring Harbor Symposia on Quantitative
Biology 31:99-102, 1966.
Last, J. A., W. M. Stanley, Jr., M. Salas, M. B. Hille, A. J. Wahba
and S. Ochoa. Translation of the genetic message. IV. UAA as a chain
termination codon. Proceedings of the National Academy of Sciences,
USA 57:1062-1067, 1967.
Boedtker, H., R. B. Crkvenjakov, J. A. Last and P. Doty. The identification
of collagen messenger RNA. Proceedings of the National Academy of Science,
USA 71:4208-4212, 1974.
Last, J.A. Biochemical and cellular interrelationships in the development
of ozone-induced pulmonary fibrosis. In: Health Effects of Air Pollution,
R. Bates (Ed.), National Academy of Sciences, Washington, D.C., PP.
415-440, 1988.
Last, J.A., P. Summers, and K.M. Reiser. Biosynthesis of collagen crosslinks.
II. In Vivo labelling and stability of lung collagen in rats. Biochimica
et Biophysica Acta 990:182-189, 1989.
Last, J.A. and K.M. Reiser. Biosynthesis of collagen crosslinks. III.
In vivo labelling and stability of lung collagen in rats with bleomycin-induced
pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 1:111-117, 1989.
Last, J.A., T.E. King, A.G. Nerlich, and K.M. Reiser. Collagen crosslinking
in adult patients with acute and chronic fibrotic lung disease: Molecular
markers for fibrotic collagen. Am. Rev. Respir. Dis. 141:307-313, 1990.
Last, J.A., J.E. Gerriets, L.C. Armstrong, T.R. Gelzleichter, and K.M.
Reiser. Hydroxylation of collagen by lungs of rats administered bleomycin.
Am. J. Respir. Cell Mol. Biol. 2:543-548, 1990.
Gerriets, J.E., Curwin, S.L., and Last, J.A. Tendon hypertrophy is associated
with increased hydroxylation of nonhelical lysine residues at two specific
crosslinking sites in Type I collagen. J. Biol. Chem., 268: 25553-25560,
1993.
Armstrong, L.C., Watkins, K., Pinkerton, K.E., and Last, J.A. Collagen
messenger RNA content and distribution in the lungs of rats exposed
to ozone. Am. J. Respir. Cell Mol. Biol., 11:25-34, 1994.
Armstrong, L.C. and Last, J.A. Rat lysyl hydroxylase: molecular cloning,
mRNA distribution, and expression in a baculovirus system. Biochimica
et Biophysica Acta, 1264: 93-102, 1995.
Bradshaw, T.K., Kennedy, K.M., Davis, P.R., Lloyd, L.L., Gwebu, N.,
and Last, J.A. Science First: Contributions of A University-Industry
Toxic Substances Research and Teaching Program to Economic Development.
Journal of Higher Education, 74:292-320, 2003.
Samimi, A. and Last, J.A. Inhibition of Lysyl Hydroxylase by Malathion
and Malaoxon, Toxicol. Appl. Pharmacol. 172: 203-209, 2001.
Samimi, A. and Last, J.A. Mechanism of the Inhibition of Lysyl Hydroxylase
by the organophosphates malathion and malaoxon. Toxicol. Appl. Pharmacol.,
176:181-186, 2001.
Kenyon, N.J. van der Vliet, A., Schock, B., Okamoto, T., McGrew, G.M.,
and Last, J.A. Susceptibility to Ozone-Induced Acute Lung Injury in
iNOS-Deficient Mice. American Journal of Physiology: Lung Cell Molecular
Physiology 282(3): L540-5, 2002.
Kenyon, N.J., Ward, R.W., and Last, J.A. Airway fibrosis in a mouse
model of airway inflammation. Toxicology and Applied Pharmacology, 186:90-100,
2003.
Gohil, K., Cross, C.E,. and Last, J.A. Ozone induced disruptions of
lung transcriptosomes. Biochemical and Biophysical Research Communications,
305:719-728, 2003.
Kenyon, N.J., Gohil, K., and Last, J.A. Susceptibility to ovalbumin-induced
airway inflammation and fibrosis in iNOS-deficient mice: mechanisms
and consequences. Toxicology and Applied Pharmacology, 191: 2-11, 2003.
Kenyon, N.J., Ward, R.W., McGrew, G., and Last, J.A. TGF-B1 causes airway
fibrosis and increased collagen I and III mRNAs in mice. Thorax, 58:772-777,
2003.
Last, J.A., Ward, R., Temple, L. and Kenyon, N. J. Ovalbumin-Induced
Airway Inflammation and Fibrosis in Mice Also Exposed to Ozone. Inhalation
Toxicology, 16:33-43, 2004.
Last, J.A., Ward, R., Temple, L., Pinkerton, K.E., and Kenyon, N. J.
Ovalbumin-Induced Airway Inflammation and Fibrosis in Mice Also Exposed
to Ultrafine Particles. Inhalation Toxicology, 16:93-102, 2004.
Rufo, C., Hammock, B.D., Gee, S.J., Last, J.A., and Gonzalez-Sapienza
G. Robust and Sensitive Monoclonal Enzyme-Linked Immunosorbent Assay
for the Herbicide Molinate. Journal of Agricultural and Food Chemistry,
52: 182-187, 2004.
Ellahueñe, M.F., Pérez-Alzola, L.P., Farfán-Urzua,
M., González-Hormazabal, P. Garay, M., Olmedo, M.I., and Last,
J.A. Preliminary evaluation of DNA damage related with the smoking habit
measured by the Comet assay in whole blood cells. Cancer Epidemiology,
Biomarkers and Prevention, 13:1223-1229, 2004.
Kenyon, N.J. and Last, J.A. Reversible and Irreversible Airway Inflammation
and Fibrosis in Mice Exposed to Inhaled Ovalbumin. Inflammation Research,
54:57-65, 2005.
Brena B.M., Arellano L., Rufo C., Last M.S., Montaño J., Cerni
E.E., Gonzalez-Sapienza, G., Last J.A. ELISA as an Affordable Methodology
for Monitoring Groundwater Contamination by Pesticides in Low-Income
Countries. Environmental Science and Technology, 39: 3896-3903, 2005.
Cardozo S., González-Techera A., Last J, Hammock B., Kramer K.,
and González-Sapienza G. Analyte peptidomimetics selected from
phage display peptide libraries: a systematic strategy for the development
of environmental immunoassays. Env. Sci. Technol. 39: 4234 – 4241,
2005.
Last J.A., Gohil K., Mathrani V.C., Kenyon N.J. Systemic Responses to
Inhaled Ozone in Mice: Cachexia and Down-regulation of Liver Xenobiotic
Metabolizing Genes. Toxicology and Applied Pharmacology, in press, 2005.